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Drugs reference index «Gatifloxacin»



Pronunciation: (ga-ti-FLOKS-a-sin)Class: Antibiotic, Fluoroquinolone, Ophthalmic

Trade Names:Zymar- Ophthalmic solution 3 mg/mL


Treatment of infections caused by susceptible strains of the designated microorganism.



C max is less than 5 ng/mL.

Indications and Usage

Treatment of bacterial conjunctivitis caused by susceptible organisms.


Standard considerations.

Dosage and Administration

Adults and Children 1 y of age and older

Ophthalmic Days 1 and 2, instill 1 drop in affected eye(s) every 2 h while awake, up to 8 times/day. Days 3 through 7, instill 1 drop up to 4 times daily while awake.

General Advice

  • For topical instillation into eye(s) only. Do not introduce directly into the anterior chamber of the eye.
  • Have patient tilt head back, pull lower lid out to make pocket, and instill medication into conjunctival sac. Have patient close eyes and apply light finger pressure to bridge of nose for 1 to 2 min. Advise patient not to blink or rub eyes.
  • If using other topical ophthalmic drugs, separate each medication by at least 5 min.


Store at controlled room temperature (59° to 77°F). Protect from freezing. Keep container tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Headache (1% to 4%).


Conjunctival irritation, increased lacrimation, keratitis, papillary conjunctivitis (5% to 10%); chemosis, conjunctival hemorrhage, dry eye, eye discharge, eye irritation, eye pain, eyelid edema, red eye, reduced visual acuity (1% to 4%).


Taste perversion (1% to 4%).



Monitor patient for signs and symptoms of ocular adverse reactions (eg, burning, stinging pain, irritation) and improvement in conjunctivitis. Notify health care provider if conjunctivitis is not improving or is worsening or if intolerable adverse reactions occur.


Category C .


Not known if excreted in human milk.


Safety and efficacy not established in patients younger than 1 yr of age.


Use of antibiotics may result in bacterial or fungal overgrowth.

Contact lenses

Patients should not wear contact lenses.

Patient Information

  • Remind patients not to wear contact lenses if signs and symptoms of bacterial conjunctivitis occur.
  • Review dosing regimen with patient.
  • Teach patient proper technique for instilling eye drops: wash hands; do not allow dropper to touch eye. Tilt head back and look up; pull lower eyelid down; instill prescribed number of drops. Close eye for 1 to 2 min and apply gentle pressure to bridge of nose. Do not rub eye.
  • Advise patient that if more than 1 topical ophthalmic drug is being used to administer the drugs at least 5 min apart.
  • Advise patient to inform health care provider if ocular adverse reactions occur and become bothersome or if infection is not improving.

Copyright © 2009 Wolters Kluwer Health.

  • Gatifloxacin Detailed Consumer Information (PDR)
  • Gatifloxacin MedFacts Consumer Leaflet (Wolters Kluwer)
  • gatifloxacin Ophthalmic Advanced Consumer (Micromedex) - Includes Dosage Information
  • Tequin Consumer Overview

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