Generic Name: hydrochlorothiazide and reserpine (hye droe klor oh THYE a zide and re SER peen)Brand names: Hydropres-25, Hydropres-50, Hydroserpine, Hydroserpine #1, Hydro-Reserp, Hydroserp
Reserpine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax and your heart to beat more slowly and easily.
Hydrochlorothiazide is a thiazide diuretic (water pill). It helps to lower your blood pressure and decrease edema (swelling) by increasing the amount of salt and water you lose in your urine.
Together, hydrochlorothiazide and reserpine are used to treat high blood pressure (hypertension).
Hydrochlorothiazide and reserpine may also be used for purposes other than those listed in this medication guide.What is the most important information I should know about hydrochlorothiazide and reserpine?Stand up slowly from a sitting or lying position. Hydrochlorothiazide and reserpine may make you feel dizzy. Do not stop taking hydrochlorothiazide and reserpine suddenly. Even if you feel better, you need this medication to control your condition. Stopping suddenly could cause severe high blood pressure, anxiety, and other dangerous side effects.
Tell your doctor and dentist that you are taking this medication before having surgery.
You must not take hydrochlorothiazide and reserpine if you
have peptic ulcer disease (stomach ulcers);
have ulcerative colitis;
are suffering from depression (especially if you have suicidal thoughts);
are receiving electroconvulsive shock therapy; or
are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate).
Before taking this medication, tell your doctor if you have
gallstones or other stomach problems,
a collagen vascular disease such as systemic lupus erythematosus,
high cholesterol or triglyceride levels,
any type of heart disease.
You may require a lower dose or special monitoring during therapy with hydrochlorothiazide and reserpine if you have any of these conditions.Hydrochlorothiazide and reserpine is in the FDA pregnancy category C. This means that it is not known whether hydrochlorothiazide will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Hydrochlorothiazide and reserpine passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from hydrochlorothiazide and reserpine therapy. You may require a lower dose of this medication. Hydrochlorothiazide and reserpine has not been approved for use by children.
Take hydrochlorothiazide and reserpine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with a full glass of water. Take hydrochlorothiazide and reserpine with food or milk if it upsets your stomach.
Do not stop taking hydrochlorothiazide and reserpine suddenly. Stopping suddenly could make your condition much worse or cause very serious side effects.Store this medication at room temperature away from moisture and heat.
See also: Hydrochlorothiazide and reserpine dosage in more detail
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Symptoms of a hydrochlorothiazide and reserpine overdose include low blood pressure (fainting, dizziness, weakness); sleepiness; uncontrollable hand, leg, or arm movements; a slow pulse; low body temperature; diarrhea; increased urination; vomiting; and slow breathing.
Avoid a diet high in salt. Too much salt will cause your body to retain water and will decrease the effects of hydrochlorothiazide.Use caution when rising from a sitting or lying position, especially first thing in the morning. You may become dizzy while taking hydrochlorothiazide and reserpine and you may fall and injure yourself if you get up quickly.
Do not let yourself become overheated in hot weather or during exercise. Also avoid standing for long periods of time and use caution if you have a fever. These situations increase the effects of hydrochlorothiazide and reserpine, and you may become very dizzy.Avoid prolonged exposure to sunlight. Hydrochlorothiazide may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Avoid alcohol. It will greatly increase the effects of hydrochlorothiazide and reserpine.
Do not take any over the counter cough, cold, allergy, sleep, or diet medications without first asking your doctor or pharmacist. These will interfere with your hydrochlorothiazide and reserpine therapy.
Use caution when you are driving, climbing ladders, or performing other hazardous activities until you know how hydrochlorothiazide and reserpine affects you. If it makes you dizzy or drowsy, avoid these activities.
Tell your doctor and dentist that you are taking this medication before having surgery.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
a very irregular heartbeat;
heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more);
abnormal bleeding or bruising;
yellow skin or eyes;
little or no urine.
Other, less serious side effects may be more likely to occur. Continue to take hydrochlorothiazide and reserpine and talk to your doctor if you experience
fatigue or drowsiness;
dizziness (avoid standing up too quickly and use caution when performing hazardous activities);
anxiety, depression, or nightmares;
diarrhea, nausea, vomiting, or an acid stomach (take hydrochlorothiazide and reserpine with food or milk if it upsets your stomach);
stuffy nose or a dry mouth (sucking on ice chips or sugarless hard candy may relieve a dry mouth);
tingling or numbness in your arms, legs, hands, or feet;
muscle weakness or cramps;
increased hunger or thirst;
sensitivity to sunlight; or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Usual Adult Dose for Hypertension:
Initial dose: 1 to 2 tablets (hydrochlorothiazide/reserpine 25 mg-0.125 mg) orally once a day or1 tablet (hydrochlorothiazide/reserpine 50 mg-0.125 mg) orally once a day. Should conform to the dosages of the individual components established during titration.
Do not take hydrochlorothiazide and reserpine if you are taking a monoamine oxidase inhibitor (MAOI), or if you have taken one in the last 14 days. MAOIs, used to treat depression, include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).
Before taking this medication, tell your doctor if you are taking any of the following medicines:
digoxin (Lanoxin) or quinidine (Cardioquin, Quinidex, Quinora, Quinaglute), which will increase the risk that you will experience an irregular heartbeat when it is taken with hydrochlorothiazide and reserpine;
barbiturates such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), and secobarbital (Seconal), which may cause extreme sleepiness or dizziness if taken with hydrochlorothiazide and reserpine;
narcotic pain relievers such as codeine (Tylenol #3, Tylenol #4, others), propoxyphene (Darvon, Darvocet, Wygesic), oxycodone (Percodan, Percocet, Tylox), meperidine (Demerol), and morphine (MS Contin, Duramorph, others), which also may cause extreme sleepiness or dizziness if taken with hydrochlorothiazide and reserpine;
steroid medications such as hydrocortisone (Hydrocortone, Cortef), prednisone (Deltasone, Orasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), betamethasone (Celestone), and dexamethasone (Decadron, Hexadrol), which may increase the side effects of hydrochlorothiazide;
prescription and over-the-counter cough, cold, allergy, diet, and sleeping pills, which may affect your condition or your treatment with hydrochlorothiazide and reserpine;
the cholesterol-lowering drugs cholestyramine (Questran) and colestipol (Colestid), which may decrease the effects of hydrochlorothiazide;
oral antidiabetic drugs such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase), which may not lower your blood sugar as well (your diabetes therapy may have to be adjusted);
lithium (Lithobid, Eskalith, others), which should not be taken with hydrochlorothiazide because serious side effects may result; or
other drugs that also lower blood pressure, including acebutolol (Sectral), atenolol (Tenormin), bisoprolol (Zebeta), carteolol (Cartrol), labetolol (Trandate, Normodyne), propranolol (Inderal), pindolol (Visken), timolol (Blocadren), benazepril (Lotensin), enalapril (Vasotec), captopril (Capoten), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), ramipril (Altace), amlodipine (Norvasc), bepridil (Vascor), diltiazem (Cardizem, Dilacor), felodipine (Plendil), isradipine (Dynacirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), and verapamil (Calan, Veralan, Isoptin).
Drugs other than those listed here may also interact with hydrochlorothiazide and reserpine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
Hydrochlorothiazide and reserpine is available with a prescription under the brand name Hydropres. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
Hydrochlorothiazide/reserpine strengths are as follows:
Hydropres 25 (25 mg/0.125 mg)--green, round, scored, compressed tablets
Hydropres 50 (50 mg/0.125 mg)--green, round, scored compressed tablets