Generic Name: hydrochlorothiazide and valsartan (HYE droe klor oh THYE a zide and val SAR tan)Brand Names: Diovan HCT
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Valsartan is in a group of drugs called angiotensin II receptor antagonists. Valsartan keeps blood vessels from narrowing, which lowers blood pressure improves blood flow.
The combination of hydrochlorothiazide and valsartan is used to treat high blood pressure (hypertension).
Hydrochlorothiazide and valsartan may also be used for other purposes not listed in this medication guide.What is the most important information I should know about hydrochlorothiazide and valsartan?Do not use this medication if you are allergic to hydrochlorothiazide or valsartan, or if you are unable to urinate. Do not use this medication without telling your doctor if you are pregnant. Valsartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment.
Before using hydrochlorothiazide and valsartan, tell your doctor if you have congestive heart failure, kidney or liver disease, asthma, low or high blood levels of potassium, gout, lupus, diabetes, or an allergy to sulfa drugs.Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of hydrochlorothiazide and valsartan.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and valsartan, unless your doctor has told you to. In rare cases, hydrochlorothiazide and valsartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.What should I discuss with my healthcare provider before taking hydrochlorothiazide and valsartan?Do not use this medication if you are allergic to hydrochlorothiazide or valsartan (Diovan), or if you are unable to urinate.
Before using hydrochlorothiazide and valsartan, tell your doctor if you have:
congestive heart failure;
asthma or allergies;
low or high levels of magnesium or potassium in your blood;
an allergy to sulfa drugs.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take hydrochlorothiazide and valsartan.FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use this medication without telling your doctor if you are pregnant. Valsartan may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. It is not known whether hydrochlorothiazide and valsartan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Take this medication with a full glass (8 ounces) of water.
To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. Do not miss any scheduled appointments.
Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using this medication.
If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.Store hydrochlorothiazide and valsartan at room temperature away from moisture and heat.
See also: Hydrochlorothiazide and valsartan dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and valsartan, unless your doctor has told you to.
feeling light-headed, fainting;
swelling, rapid weight gain;
fast or pounding heartbeats;
urinating less than usual, or not at all;
jaundice (yellowing of the skin or eyes); or
dry mouth, increased thirst, drowsiness, restless feeling, confusion, increased urination, fast heart rate, fainting, or seizure (convulsions).
Less serious side effects may include:
stomach pain, diarrhea;
headache, tired feeling, dizziness;
stuffy nose, sore throat; or
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hypertension:
Initial dose: 1 tablet (12.5 mg-80 mg) orally once a day.Maintenance dose: Titrate as necessary up to a maximum of 50 mg-320 mg orally once a day.
Before taking hydrochlorothiazide and valsartan, tell your doctor if you are using any of the following drugs:
any other blood pressure medications;
steroids (prednisone and others);
lithium (Eskalith, Lithobid);
celecoxib (Celebrex) or valdecoxib (Bextra);
cholestyramine (Prevalite, Questran) or colestipol (Colestid);
insulin or diabetes medications you take by mouth;
rifampin (Rifadin, Rimactane, Rifater);
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
any other diuretics, such as amiloride (Midamor), bumetanide (Bumex), chlorthalidone (Hygroton, Thalitone), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), indapamide (Lozol), metolazone (Mykrox, Zarxolyn), spironolactone (Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), torsemide (Demadex), and others;
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), piroxicam (Feldene), and others;
a muscle relaxer such as baclofen (Lioresal), carisoprodol (Soma), cyclobenzaprine (Flexeril), dantrolene (Dantrium), metaxalone (Skelaxin), or methocarbamol (Robaxin), orphenadrine (Norflex), or tizanidine (Zanaflex);
a narcotic medication such as hydrocodone (Lortab, Vicodin), hydromorphone (Dilaudid, Palladone), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Methadose), morphine (Kadian, MS Contin), oxycodone (OxyContin), oxymorphone (Numorphan), or propoxyphene (Darvon, Darvocet).
This list is not complete and there may be other drugs not listed that can affect hydrochlorothiazide and valsartan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.