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Drugs reference index «Hydrochlorothiazide/Spironolactone»



Generic Name: Hydrochlorothiazide/Spironolactone (HYE-droe-KLOR-oh-THYE-a-zide/spir-ON-oh-LAK-tone)Brand Name: Aldactazide

Hydrochlorothiazide/Spironolactone can increase potassium levels in your body. This is more likely to occur in elderly patients, patients who are severely ill, patients with heart failure, or patients with kidney problems and diabetes. If not treated, high potassium levels can be fatal. Potassium levels must be closely monitored in people with any of these problems or illnesses. Lab tests will be required so be sure to keep appointments. If you develop muscle weakness or an unusual heartbeat, notify your doctor immediately.

Spironolactone, an ingredient in Hydrochlorothiazide/Spironolactone , has been shown to cause tumors in rats when given to them over a long period of time. Hydrochlorothiazide/Spironolactone should be used only when necessary to treat the conditions for which it is indicated.

Hydrochlorothiazide/Spironolactone is used for:

Treating swelling in patients who have congestive heart failure, cirrhosis of the liver, or certain kidney problems (eg, nephrotic syndrome) when other treatments are not effective or appropriate. It is also used to treat high blood pressure in patients for whom other treatments are not effective or appropriate.

Hydrochlorothiazide/Spironolactone is a combination of a potassium-sparing diuretic (spironolactone) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The spironolactone component helps minimize potassium loss.

Do NOT use Hydrochlorothiazide/Spironolactone if:

  • you are allergic to any ingredient in Hydrochlorothiazide/Spironolactone or any other sulfonamide (eg, sulfamethoxazole)
  • you are unable to urinate or have severely decreased kidney function, severe liver problems, or high blood potassium
  • you are taking another potassium-sparing diuretic (eg, triamterene), a potassium supplement, a salt substitute containing potassium, or dofetilide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hydrochlorothiazide/Spironolactone :

Some medical conditions may interact with Hydrochlorothiazide/Spironolactone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems (eg, heart failure), menstrual problems, or systemic lupus erythematosus (SLE or lupus)
  • if you have high cholesterol or triglyceride levels, elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated

Some MEDICINES MAY INTERACT with Hydrochlorothiazide/Spironolactone . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin II receptor antagonists (eg, valsartan), cyclosporine, macrolide immunosuppressives (eg, tacrolimus), other aldosterone-blockers (eg, eplerenone), other potassium sparing diuretics (eg, amiloride, triamterene), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur (eg, listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, potentially life-threatening slow or irregular heartbeat)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Hydrochlorothiazide/Spironolactone 's effectiveness, and the risk of high blood potassium or kidney problems may be increased
  • Cholestyramine or colestipol because they may decrease Hydrochlorothiazide/Spironolactone 's effectiveness
  • Barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), diazoxide, digoxin, dofetilide, ketanserin, lithium, narcotic pain medicines (eg, codeine), nondepolarizing neuromuscular blockers (eg, tubocurarine), or medicines for high blood pressure because the risk of their side effects may be increased by Hydrochlorothiazide/Spironolactone
  • Diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Hydrochlorothiazide/Spironolactone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydrochlorothiazide/Spironolactone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hydrochlorothiazide/Spironolactone :

Use Hydrochlorothiazide/Spironolactone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Hydrochlorothiazide/Spironolactone by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Hydrochlorothiazide/Spironolactone may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Hydrochlorothiazide/Spironolactone , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, restart the medication and advise your doctor or pharmacist at your next appointment.

Ask your health care provider any questions you may have about how to use Hydrochlorothiazide/Spironolactone .

Important safety information:

  • Hydrochlorothiazide/Spironolactone may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrochlorothiazide/Spironolactone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Hydrochlorothiazide/Spironolactone may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Hydrochlorothiazide/Spironolactone can raise your body's potassium levels. This is more likely to occur in people with kidney problems or diabetes, people with heart failure, or the elderly, or if the patient is severely ill. Potassium levels must be closely monitored in people with any of these problems or illnesses. If not treated, high potassium levels can be fatal.
  • Hydrochlorothiazide/Spironolactone may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hydrochlorothiazide/Spironolactone . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Hydrochlorothiazide/Spironolactone before you receive any medical or dental care, emergency care, or surgery.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Diabetes patients - Hydrochlorothiazide/Spironolactone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Hydrochlorothiazide/Spironolactone may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Hydrochlorothiazide/Spironolactone .
  • Lab tests, including liver function, kidney function, lung function, blood pressure, blood electrolytes, and fasting blood glucose, may be performed while you use Hydrochlorothiazide/Spironolactone . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Hydrochlorothiazide/Spironolactone should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Hydrochlorothiazide/Spironolactone can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrochlorothiazide/Spironolactone while you are pregnant. Hydrochlorothiazide/Spironolactone is found in breast milk. Do not breast-feed while taking Hydrochlorothiazide/Spironolactone .

Possible side effects of Hydrochlorothiazide/Spironolactone :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; fatigue; headache; loss of appetite; nausea; stomach upset; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; breast enlargement; confusion; dark urine; decreased urination or change in the amount of urine produced; dry mouth; excessive thirst; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; impotence; leg or muscle cramps, pain, or weakness; menstrual changes; restlessness; severe or persistent dizziness, weakness, or fatigue; stomach pain; unusual bruising or bleeding; unusual skin sensations; unusual weight loss; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include excessive urination; flushed face; lightheadedness especially upon standing; nausea; vomiting; weakness.

Proper storage of Hydrochlorothiazide/Spironolactone :

Store Hydrochlorothiazide/Spironolactone at room temperature, below 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrochlorothiazide/Spironolactone out of the reach of children and away from pets.

General information:

  • If you have any questions about Hydrochlorothiazide/Spironolactone , please talk with your doctor, pharmacist, or other health care provider.
  • Hydrochlorothiazide/Spironolactone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hydrochlorothiazide/Spironolactone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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