Idursulfase may sometimes cause severe and possibly fatal allergic reactions. Tell your doctor at once if you develop trouble breathing; tightness in the chest; severe dizziness; swelling of the mouth, face, lips, or tongue; hoarseness; or seizures. You should receive Idursulfase only under medical supervision in a facility where treatment for an allergic reaction is available in case it occurs.
Tell your doctor if you have lung or breathing problems. Sudden and serious worsening of your breathing problems could occur if you have an allergic reaction. Discuss any questions or concerns with your doctor.
Treating Hunter syndrome (mucopolysaccharidosis type II; MPS II).
Idursulfase is a lysosomal enzyme. It works in by increasing the amount of iduronate-2-sulfatase in patients with Hunter syndrome who do not make this enzyme on their own.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Idursulfase . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Idursulfase . However, no specific interactions with Idursulfase are known at this time.
Ask your health care provider if Idursulfase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Idursulfase as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Idursulfase .
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Anxiety; general unwell feeling; headache; irritability; pain, swelling, or redness at the injection site; stomach upset.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue/purple discoloration of lips, nails, or skin; chest pain; fever; hoarseness; irregular heartbeat; joint pain; seizures; severe headache or dizziness; shortness of breath; vision changes; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.Proper storage of Idursulfase :
Idursulfase is usually handled and stored by a health care provider. If you are using Idursulfase at home, store Idursulfase as directed by your pharmacist or health care provider. Keep Idursulfase out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Idursulfase . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.