Generic Name: chlorambucil (klor AM bue sil)Brand Names: Leukeran
Chlorambucil is a cancer medication that interferes with cancer cells and slows their growth and spread in the body.
Chlorambucil is used to treat several types of cancer, including Hodgkin's disease and certain types of leukemia or lymphoma.
Chlorambucil may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Leukeran (chlorambucil)?Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.
Treatment with chlorambucil may increase your risk of developing other forms of cancer. This medication can also affect fertility (your ability to have children), whether you are a man or a woman. Talk to your doctor about your specific risks when using chlorambucil.
Chlorambucil can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.
Do not receive a "live" vaccine while you are being treated with chlorambucil.Stop using chlorambucil and call your doctor at once if you have a seizure, red or peeling skin rash, severe nausea or stomach pain, jaundice (yellowing of your skin or eyes), any unusual mass or lump, fever, chills, sore throat, cough, flu-like symptoms, pale skin, easy bruising or bleeding, unusual weakness, white patches or sores inside your mouth or on your lips, or missed menstrual periods.What should I discuss with my healthcare provider before taking Leukeran (chlorambucil)?You should not use this medication if you are allergic to chlorambucil, or if you have received this medication in the past without successful treatment of your condition.
If you have received radiation treatment within the past 4 weeks, you may need a dose adjustment or special tests to safely take chlorambucil.FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use chlorambucil without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.
This medication can affect fertility (your ability to have children), whether you are a man or a woman.It is not known whether chlorambucil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Treatment with chlorambucil may increase your risk of developing other forms of cancer. Talk to your doctor about your specific risk.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. You should not take chlorambucil unless you remain under the care of a doctor.Take this medicine with a full glass of water.
Chlorambucil can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.Store chlorambucil in the refrigerator but do not allow it to freeze.
See also: Leukeran dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include agitation, loss of balance or coordination, or seizure (convulsions).
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while you are being treated with chlorambucil.
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
an unusual mass or lump;
fever, chills, body aches, flu symptoms, or ongoing cough;
pale skin, easy bruising or bleeding, unusual weakness;
white patches or sores inside your mouth or on your lips;
severe nausea, vomiting, or diarrhea; or
missed menstrual periods.
Less serious side effects:
upset stomach, mild nausea, diarrhea;
tremors or shaking; or
numbness or tingling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
There may be other drugs that can affect chlorambucil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.