Trade Names:Arestin- Microspheres, sustained-release 1 mg (as hydrochloride)
Trade Names:Dynacin- Tablets 50 mg (as hydrochloride)- Tablets 75 mg (as hydrochloride)- Tablets 100 mg (as hydrochloride)- Capsules 50 mg (as hydrochloride)- Capsules 100 mg (as hydrochloride)
Trade Names:Minocin- Capsules, pellet-filled 50 mg (as hydrochloride)- Capsules, pellet-filled 100 mg (as hydrochloride)- Injection, lyophilized powder for solution 100 mg (as hydrochloride)
Trade Names:Minocycline HCl- Tablets, extended-release 45 mg- Tablets, extended-release 90 mg- Tablets, extended-release 135 mgApo-Minocycline (Canada)Enca (Canada)Gen-Minocycline (Canada)ratio-Minocycline (Canada)Sandoz Minocycline (Canada)
Inhibits bacterial protein synthesis.
T max is 1 to 4 h after a single dose. Food does not affect extent of absorption, but C max is slightly decreased and delayed by 1 h.
Minocycline has a very high lipid solubility, readily penetrates the CSF, and displays a good penetration of saliva, brain, eye, and prostate. 70% to 80% is protein bound.
Metabolism is concentrated by the liver in the bile.
1% to 12% is excreted unchanged in urine. Serum t ½ is approximately 11 to 23 h in healthy volunteers. Hemodialysis and peritoneal dialysis have little effect.
Serum t ½ is 18 to 69 h.Hepatic Function Impairment
Serum t ½ is 11 to 16 h.
Treatment of periodontitis as an adjunct to scaling and root planing. Treatment of infections caused by susceptible strains of gram-positive and gram-negative bacteria, Rickettsia and Mycoplasma pneumonia, and trachoma; treatment for susceptible infections when penicillins are contraindicated; adjunctive treatment of acute intestinal amebiasis; treatment of asymptomatic carriers of Neisseria meningitidis to eliminate meningococci from nasopharynx, chlamydia, inflammatory acne, syphilis, gonorrhea.
PO 50 mg 1 to 3 times per day.Meningococcal Carrier StateAdults
PO 100 mg every 12 h for 5 days.Mycobacterium Marinum InfectionsAdults
PO 100 mg every 12 h for 6 to 8 wk, although optimal doses have not been established.PeriodontitisAdults
Subgingival 1 mg microspheres are to be inserted by an oral health care professional.Primary/Secondary SyphilisAdults
PO 200 mg initially then 100 mg every 12 h for 10 to 15 days.Renal Function Impairment
Do not exceed 200 mg per 24 h.Susceptible InfectionsAdults
PO/IV 200 mg initially, then PO/IV 100 mg every 12 h or PO 50 mg 4 times daily (max, parenteral 400 mg per 24 h).Children older than 8 yr of age
PO/IV 4 mg/kg initially, then 2 mg/kg every 12 h (max, usual adult dose).Uncomplicated Gonococcal Infections Except Urethritis and Anorectal Infections in MenAdults
PO 200 mg initially followed with 100 mg every 12 h for at least 4 days, with posttherapy cultures within 2 to 3 days.Uncomplicated Gonococcal Urethritis in MenAdults
PO 100 mg every 12 h for 5 days.Uncomplicated Urethral, Endocervical, or Rectal Infections in Adults Caused by C. Trachomatis or Ureaplasma UrealyticumAdults
PO 100 mg every 12 h for at least 7 days.
Store capsules at controlled room temperature (68° to 77°F). Protect from light, moisture, and excessive heat. Diluted solution should be administered immediately, but can be stored at room temperature (68° to 77°F) for up to 24 h. Discard any unused solution after 24 h. Store powder for injection at controlled room temperature (68° to 77°F). Protect from light moisture and excessive heat. Store at controlled room temperature (59° to 86°F). Avoid exposure to excessive heat.
May decrease oral absorption of minocycline.Anticoagulants, oral
Increased anticoagulant activity.Contraceptives, oral
May reduce effect of oral contraceptives.Digoxin
May increase digoxin serum levels.Insulin
Increases hypoglycemic potential.Iron salts
May decrease absorption of minocycline.Isotretinoin
Because the risk of pseudotumor cerebri may be increased, avoid isotretinoin administration shortly before, during, or after minocycline therapy.Methoxyflurane
Increased potential for nephrotoxicity exists; do not coadminister.Milk and dairy products
Although the effects of milk and dairy products on minocycline absorption are less than observed with other tetracycline derivatives, it would be prudent to avoid the administration of milk or dairy products with all tetracycline derivatives.Penicillins
May interfere with bactericidal action of penicillins.Urinary alkalinizers, zinc salts
May decrease serum minocycline levels.
Do not mix before or during administration with adrenocorticotropic hormone, aminophylline, amobarbital sodium, amphotericin B, bicarbonate infusion mixtures, calcium gluconate or chloride, carbenicillin, cephalothin sodium, cefazolin sodium, chloramphenicol succinate, colistin sulfate, heparin sodium, hydrocortisone sodium succinate, iodine sodium, methicillin sodium, novobiocin, penicillin, pentobarbital, phenytoin sodium, polymyxins, prochlorperazine, sodium ascorbate, sulfadiazine, sulfisoxazole, thiopental sodium, vitamin K (sodium bisulfate or sodium salt), whole blood.
False increase in urinary catecholamines with fluorometric method.
Convulsions; dizziness; hypoesthesia; paresthesia; sedation; vertigo; bulging fontanels in infants; benign intracranial hypertension (pseudotumor cerebri) in adults; headache.
Alopecia; erythema nodosum; hyperpigmentation of nails; pruritus; toxic epidermal necrolysis; vasculitis; maculopapular and erythematous rashes; exfoliative dermatitis; fixed drug eruptions; balanitis due to lesions on the penis; erythema multiforme; Stevens-Johnson syndrome; photosensitivity.
Tinnitus; decreased hearing.
Anorexia; nausea; vomiting; diarrhea; dyspepsia; stomatitis; glossitis; dysphagia; enamel hypoplasia; enterocolitis; pseudomembranous colitis; pancreatitis; inflammatory lesions (with monilial overgrowth) in oral and anogenital regions; esophagitis; esophageal ulceration; tooth discoloration; oral cavity discoloration (including tongue, lips, and gums).
Hyperbilirubinemia; hepatic cholestasis; increased liver enzymes, fatal hepatic failure; jaundice; hepatitis (including autoimmune hepatitis); liver failure.
Agranulocytosis; hemolytic anemia; thrombocytopenia; leukopenia; neutropenia; pancytopenia; eosinophilia.
Urticaria; angioneurotic edema; polyarthralgia; anaphylaxis/anaphylactoid reaction (including shock and death); anaphylactoid purpura; myocarditis; pericarditis; exacerbation of SLE; pulmonary infiltrates with eosinophilia; transient lupus-like syndrome; serum sickness-like reactions; hypersensitivity syndrome (including rash, exfoliative dermatitis, eosinophilia, fever, lymphadenopathy and one or more of the following hepatitis, pneumonitis, nephritis, myocarditis, pericarditis).
Arthralgia; arthritis; bone discoloration; myalgia; joint stiffness; joint swelling.
Interstitial nephritis; elevations in BUN; reversible renal failure.
Cough; dyspnea; bronchospasm; exacerbation of asthma; pneumonitis.
Fever, discoloration of secretions; brown-black microscopic discoloration of the thyroid gland.
Category D .
Excreted in breast milk. Advise against breast-feeding.
Avoid in children younger than 8 yr of age unless other appropriate drugs are ineffective or contraindicated because abnormal bone formation and discoloration of teeth may occur.
May increase BUN, may lead to azotemia, hyperphosphatemia, and acidosis.
Prolonged use may result in bacterial or fungal overgrowth.
May cause exaggerated sunburn reactions.
Do not use outdated product; degraded product is highly nephrotoxic.
Has been reported. Use with caution in patients with hepatic function impairment and in conjunction with hepatotoxic drugs.
Prolonged periods of parenteral use may result in thrombophlebitis.
Has been reported in adults. Usual manifestations are headache and blurred vision.
May cause permanent discoloration of the teeth.
Dizziness, nausea, vomiting.
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