Drugs Information Online
Drugs and diseases reference index

Drugs and diseases reference index

Drugs reference index «Nexium»



Generic Name: esomeprazole (Oral route, Intravenous route)


Commonly used brand name(s):

In the U.S.

  • Nexium
  • Nexium I.V.

Available Dosage Forms:

  • Packet
  • Capsule, Delayed Release
  • Powder for Solution

Therapeutic Class: Gastric Acid Secretion Inhibitor

Pharmacologic Class: Proton Pump Inhibitor

Uses For Nexium

Esomeprazole is used to treat conditions in which there is too much acid in the stomach. It is used to treat duodenal ulcers and gastroesophageal reflux disease (GERD). This is a condition in which the acid in the stomach washes back up into the esophagus. It also reduces the chance of gastric ulcers in patients who use a group of medicines called NSAIDs and who may be at greater risk (i.e., patients 60 years of age or older or patients who have a history of gastric ulcers). Sometimes esomeprazole is used along with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria (germ).

Esomeprazole is also used to treat Zollinger-Ellison syndrome and other conditions that cause the stomach to produce too much acid .

Esomeprazole works by decreasing the amount of acid produced by the stomach.

This medicine is available only with your doctor's prescription.

Before Using Nexium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of esomeprazole in children 1 to 17 years of age. Safety and efficacy have not been established in children younger than 1 year of age .


Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of esomeprazole in the elderly .


Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atazanavir
  • Clopidogrel
  • Dasatinib
  • Erlotinib
  • Mycophenolate Mofetil
  • Nelfinavir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cranberry
  • Posaconazole
  • Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease, or a history of—This condition may cause esomeprazole to build up in the body.

Proper Use of esomeprazole

This section provides information on the proper use of a number of products that contain esomeprazole. It may not be specific to Nexium. Please read with care.

If you are taking the capsule form of this medicine: Take esomeprazole at least one hour before a meal.

Swallow the capsule whole. Do not crush, break, or chew the capsule. If you cannot swallow the capsule whole, you may open it and sprinkle the granules contained in the capsule on one tablespoonful of applesauce or yogurt and swallow it immediately; or you may mix the granules in some tap water or fruit juice and drink it immediately. The applesauce should not be hot, and the juices you may use include apple or orange juice. Do not chew or crush the granules.

To use the delayed-release oral suspension:

  • Empty the contents of esomeprazole packet into a container with 1 tablespoon (15 mL) of water.
  • Stir well.
  • Leave 2 to 3 minutes to thicken.
  • Stir and drink within 30 minutes.
  • If any medicine remains after drinking, add more water, stir, and drink immediately .

The delayed-release oral suspension or the contents inside the delayed-release capsule may be given through a nasogastric (NG) tube. Use only a catheter tipped syringe to give esomeprazole through an NG tube .

If you are using the delayed-release capsule with a nasogastric tube:

  • Open the capsule and empty the granules into a 60 mL catheter tipped syringe and mix with 50 mL of water.
  • Replace the plunger and shake the syringe well for 15 seconds.
  • Hold the syringe with the tip up and check for granules in the tip.
  • Attach the syringe to the nasogastric tube. Give the medicine in the syringe through the nasogastric tube into the stomach.
  • Rinse the nasogastric tube with more water after giving the granules .

If you are using the delayed-release oral suspension with a nasogastric tube:

  • Add 15 mL of water to a catheter tipped syringe and add the contents of esomeprazole packet.
  • Shake the syringe right away and leave it for 2 to 3 minutes to thicken.
  • Shake the syringe and give the medicine through the nasogastric tube into the stomach within 30 minutes.
  • Refill the syringe with 15 mL of water.
  • Shake and flush any remaining contents from the nasogastric tube into the stomach .

Take this medicine for the full time of treatment, even if you begin to feel better. Also, keep your appointments with your doctor for check-ups so that your doctor will be better able to tell you when to stop taking this medicine.

Follow your doctor's instructions for switching from the injectable form of esomeprazole to the capsule form.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (delayed-release capsules or suspension):
    • To treat gastroesophageal reflux disease (GERD):
      • Adults—20 or 40 milligrams (mg) taken once a day for 4 to 8 weeks.
      • Children 12 to 17 years of age—20 or 40 mg taken once a day for up to 8 weeks.
      • Children 1 to 11 years of age—10 or 20 mg taken once a day for up to 8 weeks.
      • Children younger than 1 year of age—Use and dose must be determined by your doctor .
    • To prevent gastroesophageal reflux disease (GERD):
      • Adults—20 mg taken once a day.
      • Children—Use and dose must be determined by your doctor.
    • To treat ulcer related infection with H. pylori:
      • Adults—40 mg once daily, plus amoxicillin 1000 mg (1 gram) plus clarithromycin 500 mg, taken together before meals twice a day for 10 days.
      • Children—Use and dose must be determined by your doctor.
    • To treat conditions that increase acids in the stomach (e.g., Zollinger-Ellison syndrome):
      • Adults—40 mg two times a day.
      • Children—Use and dose must be determined by your doctor .
  • For injection dosage form:
    • To treat gastroesophageal reflux disease (GERD):
      • Adults—20 or 40 milligrams (mg) once a day for no more than 10 days.
      • Children up to 18 years of age—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Nexium

It is very important that your doctor check you at regular visits. If your condition does not improve, or if it becomes worse, discuss this with your doctor.

Nexium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known
  • Blistering, peeling, loosening of skin
  • bloating
  • chills
  • cough
  • darkened urine
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives
  • indigestion
  • itching
  • joint or muscle pain
  • loss of appetite
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots in mouth or on lips
  • tightness in chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • belching
  • heartburn
  • indigestion
  • stomach discomfort, upset, or pain
Less common
  • Abdominal pain
  • burning, itching, redness, skin rash, swelling or soreness at injection site
  • constipation
  • diarrhea
  • dryness of mouth
  • gas
  • headache
  • nausea
  • pain or tenderness around eyes and cheekbones
  • sneezing
  • stuffy or runny nose
  • tightness of chest or wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

  • Nexium Detailed Consumer Information (PDR)
  • Nexium Consumer Overview
  • Nexium Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)
  • Esomeprazole Professional Patient Advice (Wolters Kluwer)
  • Esomeprazole MedFacts Consumer Leaflet (Wolters Kluwer)
  • Nexium Prescribing Information (FDA)
  • Nexium I.V. Consumer Overview

See Also...

Comment «Nexium»