Pangestyme EC

Generic Name: pancrelipase (Oral route)

AM-i-lase, LYE-pase, PROE-tee-ase

Commonly used brand name(s):

In the U.S.

• Creon
• Palcaps
• Pancrelipase
• Pangestyme EC
• Panocaps
• Ultracaps
• Ultrase MT
• Zenpep

In Canada

• Viokase

Available Dosage Forms:

• Capsule, Delayed Release
• Capsule
• Tablet
• Tablet, Chewable
• Powder

Therapeutic Class: Digestant

Pharmacologic Class: Enzyme

Uses For Pangestyme EC

Pancrelipase is used to help improve food digestion in certain conditions (e.g., cystic fibrosis) where the pancreas is not working properly.

Pancrelipase contains the enzymes needed for the digestion of proteins, starches, and fats.

This medicine is available only with your doctor's prescription.

Before Using Pangestyme EC

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pancrelipase in children.

Geriatric

No information is available on the relationship of age to the effects of pancrelipase in geriatric patients.

Pregnancy

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Gout or
• Hyperuricemia (high uric acid in the blood) or
• Intestinal blockage, history of or
• Kidney disease or
• Pancreatitis (inflammation of the pancreas)—Use with caution. May make these conditions worse.

Proper Use of pancrelipase

This section provides information on the proper use of a number of products that contain pancrelipase. It may not be specific to Pangestyme EC. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take this medicine with meals or snacks, unless otherwise directed by your doctor.

When prescribing this medicine for your condition, your doctor may also prescribe a personal diet for you. Follow the special diet carefully. This is necessary for the medicine to work properly. It is also important to drink plenty of water while you are on this medicine.

For patients taking the tablets:

• Swallow the tablets quickly with some liquid, without chewing, to avoid mouth irritation.

For patients taking the delayed-release capsules:

• Swallow the capsule whole.
• Do not crush, break, or chew before swallowing.
• When given to children, the capsule may be opened and sprinkled on a small amount of soft food that can be swallowed without chewing, such as applesauce or gelatin. This mixture must be swallowed immediately and followed with a glass of water or juice. This will ensure complete swallowing of the contents of the capsule and avoid mouth irritation.
• When given to infants, the contents of the capsule may be put directly into the infant's mouth or mixed with a small amount of applesauce and given before each feeding.
• Do not mix the contents of the capsule with alkaline foods, such as milk, breast milk, formula, or ice cream. This could reduce the effect of the medicine.

Do not change brands or dosage forms of pancrelipase without first checking with your doctor. Different products may not work in the same way. If you refill your medicine and it looks different, check with your pharmacist.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• To help digestion:
  • For oral dosage form (capsules):
    • Older adults, adults, and teenagers—One to three capsules before or with meals and snacks. Your doctor may change your dose if needed.
    • Children—The contents of one to three capsules sprinkled on food at each meal. Your doctor may change your dose if needed.
  • For oral dosage form (delayed-release capsules):
    • Older adults, adults, teenagers, and children older than 4 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is 500 lipase units per kilogram (kg) of body weight per meal. However, the dose is usually not more than 2500 lipase units per kg of body weight per meal (or less than or equal to 10,000 lipase units per kg of body weight per day).
    • Children older than 12 months and younger than 4 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is 1000 lipase units per kilogram (kg) of body weight per meal. However, the dose is usually not more than 2500 lipase units per kg of body weight per meal (or less than or equal to 10,000 lipase units per kg of body weight per day).
    • Infants younger than 12 months—2000 to 4000 lipase units per 120 milliliters (mL) of infant formula or per breastfeeding.
  • For oral dosage form (powder):
    • Older adults, adults, and teenagers—1/4 teaspoonful (0.7 gram) with meals and snacks. Your doctor may change your dose if needed.
    • Children—1/4 teaspoonful with meals. Your doctor may change your dose if needed.
  • For oral dosage form (tablets):
    • Older adults, adults, and teenagers—One to three tablets before or with meals and snacks. Your doctor may change your dose if needed.
    • Children—One to two tablets with meals.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Pangestyme EC

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

For patients taking the capsules containing the powder:

• If the capsules are opened to mix with food, be careful not to breathe in the powder. To do so may cause harmful effects such as stuffy nose, shortness of breath, troubled breathing, wheezing, or tightness in the chest.

For patients taking the powder form of this medicine:

• Avoid breathing in the powder. To do so may cause harmful effects such as stuffy nose, shortness of breath, troubled breathing, wheezing, or tightness in the chest.

Check with your doctor right away if you have unusual or severe abdominal or stomach pain. These may be symptoms of a rare but serious bowel disorder called fibrosing colonopathy.

This medicine is made from the pancreas of pigs. The risk of getting a virus from medicines made of pig organs has been greatly reduced in recent years. This is the result of required testing for certain viruses, and testing during manufacture of these medicines. Although the risk of transmitting certain viruses to people who will use the medicine is low, talk with your doctor if you have concerns.

This medicine may cause a serious type of allergic reaction, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have itching; hives; hoarseness; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Pangestyme EC Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

• Skin rash or hives

• Diarrhea
• intestinal blockage
• nausea
• stomach cramps or pain

• Blood in the urine
• joint pain
• swelling of the feet or lower legs

• Shortness of breath
• stuffy nose
• tightness in the chest
• troubled breathing
• wheezing

• Irritation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.