Generic Name: rifampin (rif AM pin)Brand Names: Rifadin
Rifampin is an antibiotic. Rifampin prevents bacteria from spreading in your body.
Rifampin is used to treat or prevent tuberculosis (TB).
Rifampin may also be used to eliminate a bacteria from your nose and throat that may cause meningitis or other infections, even if you do not have an infection. Rifampin prevents you from spreading this bacteria to other people, but the medication will not treat an infection caused by the bacteria.
Rifampin may also be used for other purposes not listed in this medication guide.
Before taking rifampin, tell your doctor if you are allergic to any drugs, or if you have liver disease or porphyria ( (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Rifampin will not treat a viral infection such as the common cold or flu. Take the rifampin capsule on an empty stomach 1 hour before or 2 hours after a meal. Rifampin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking rifampin. There are many other medicines that can interact with rifampin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
Do not wear contact lenses while you are taking rifampin. This medicine may discolor your tears, which could permanently stain soft contact lenses.What should I discuss with my healthcare provider before using Rifadin (rifampin)?You should not use this medication if you are allergic to rifampin.
Before taking rifampin, tell your doctor if you are allergic to any drugs, or if you have:
liver disease; or
porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
If you have any of these conditions, you may need a dose adjustment or special tests to safely take rifampin.FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Rifampin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking rifampin. Rifampin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.Take the rifampin capsule on an empty stomach 1 hour before or 2 hours after meals. Swallow the capsule with a full glass (8 ounces) of water. Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Rifampin will not treat a viral infection such as the common cold or flu. Store this medication at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up a missed dose.
Overdose symptoms may include nausea, vomiting, itching, headache, weakness, fast or uneven heart rate, or feeling like you might pass out.
Do not wear contact lenses while you are taking rifampin. This medicine may discolor your tears, which could permanently stain soft contact lenses.
fever, chills, body aches, flu symptoms;
joint pain or swelling;
easy bruising or bleeding, weakness;
urinating less than usual or not at all; or
nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
tired feeling; or
red or orange colored urine, stools, tears, sweat, or saliva.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with rifampin. Below is just a partial list. Tell your doctor if you are using:
a blood thinner such as warfarin (Coumadin);
a barbiturate such as phenobarbital (Solfoton);
diazepam (Valium) or similar medicines such as alprazolam (Xanax), chlordiazepoxide (Librium), midazolam (Versed), temazepam (Restoril), triazolam (Halcion), and others;
a beta-blocker such as atenolol (Tenormin), bisoprolol (Zebeta, Ziac), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), timolol (Blocadren), and others;
steroids such as prednisone, fluticasone (Advair), mometasone (Asmanex, Nasonex), dexamethasone (Decadron, Hexadrol) and others;
birth control pills or estrogen hormone replacement;
heart medicines such as digoxin (Lanoxin), disopyramide (Norpace), quinidine (Quinaglute, Quinidex), mexiletine (Mexitil), tocainide (Tonocard), verapamil (Calan, Verelan, Isoptin), or enalapril (Vasotec);
HIV medicines such as delavirdine (Rescriptor), saquinavir (Invirase, Fortovase), ritonavir (Norvir), nelfinavir (Viracept), and others;
ketoconazole (Nizoral), itraconazole (Sporanox), or fluconazole (Diflucan);
phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);
sulfa drugs (Bactrim, Gantanol, Septra, and others);
diabetes medication you take by mouth;
cyclosporine (Sandimmune, Neoral); or
theophylline (Elixophyllin, TheoCap, Theochron, Uniphyl).