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Drugs reference index «Sinequan»



Generic name: Doxepin hydrochlorideBrand names: Sinequan

Why is Sinequan prescribed?

Sinequan is used in the treatment of depression and anxiety. It helps relieve tension, improve sleep, elevate mood, increase energy, and generally ease the feelings of fear, guilt, apprehension, and worry most people experience. It is effective in treating people whose depression and/or anxiety is psychological, associated with alcoholism, or a result of another disease (cancer, for example) or psychotic depressive disorders (severe mental illness). It is in the family of drugs called tricyclic antidepressants.

Most important fact about Sinequan

Serious, sometimes fatal, reactions have occurred when Sinequan is used in combination with drugs known as MAO inhibitors, including the antidepressants phenelzine andtranylcypromine. Any drug of this type should be discontinued at least 2 weeks prior to starting treatment with Sinequan, and you should be carefully monitored by your doctor.

If you are taking any prescription or nonprescription drugs, consult your doctor before taking Sinequan.

How should you take Sinequan?

Take Sinequan exactly as prescribed. It may take several weeks for you to feel better.

  • If you miss a dose...If you are taking several doses a day, take the missed dose as soon as you remember, then take any remaining doses for that day at evenly spaced intervals. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

If you are taking a single dose at bedtime and do not remember until the next morning, skip the dose. Do not take a double dose to make up for a missed one.

  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Sinequan.

  • Side effects may include:Blurred vision, constipation, dizziness, drowsiness, dry mouth, itchy or scaly skin (pruritus), light sensitivity, low blood pressure, nausea, rapid or irregular heartbeat, rash, trouble urinating, water retention

Why should Sinequan not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Sinequan or similar antidepressants, you should not take Sinequan. Make sure that your doctor is aware of any drug reactions that you have experienced.

Unless you are directed to do so by your doctor, do not take Sinequan if you have the eye condition known as glaucoma or difficulty urinating.

Special warnings about Sinequan

In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Sinequan or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Sinequan is not approved for treating anyone less than 12 years old.

Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Sinequan and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly—especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior—and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose.

Sinequan may cause you to become drowsy or less alert; driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.

Notify your doctor or dentist that you are taking Sinequan if you have a medical emergency, and before you have surgery or dental treatment.

Possible food and drug interactions when taking Sinequan

Alcohol increases the danger in a Sinequan overdose. Do not drink alcohol while taking Sinequan.

Never combine Sinequan with drugs known as MAO inhibitors. Medications in this category include the antidepressants phenelzine and tranylcypromine.

If you are switching from fluoxetine, wait at least 5 weeks after your last dose of fluoxetine before starting Sinequan.

If Sinequan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Sinequan with the following:

Antidepressants that act on serotoninOther antidepressants such as amitriptyline nefazodoneCarbamazepineCimetidineClonidineFlecainideGuanethidineMajor tranquilizersPropafenoneQuinidineTolazamide

Special information if you are pregnant or breastfeeding

The effects of Sinequan during pregnancy have not been adequately studied. If you are pregnant or planning to become pregnant, inform your doctor immediately. Sinequan may appear in breast milk and could affect a nursing infant. If Sinequan is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Recommended dosage for Sinequan


The starting dose for mild to moderate illness is usually 75 milligrams per day. This dose can be increased or decreased by your doctor according to individual need. The usual ideal dose ranges from 75 milligrams per day to 150 milligrams per day, although it can be as low as 25 to 50 milligrams per day. The total daily dose can be given once a day or divided into smaller doses. If you are taking Sinequan once a day, the recommended dose is 150 milligrams at bedtime.

The 150-milligram capsule strength is intended for long-term therapy only and is not recommended as a starting dose.

For more severe illness, gradually increased doses of up to 300 milligrams may be required as determined by your doctor.


Safety and effectiveness have not been established for use in children under 12 years of age.


Due to a greater risk of drowsiness and confusion, older people are usually started on a low dose.


An overdose of Sinequan can be fatal. If you experience any of these symptoms, seek medical attention immediately.

  • Symptoms of Sinequan overdose may include:Agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low body temperature, irregular heartbeat, overactive reflexes, rigid muscles, severely low blood pressure, stupor, vomiting
  • Sinequan Prescribing Information (FDA)
  • Sinequan MedFacts Consumer Leaflet (Wolters Kluwer)
  • Sinequan Concise Consumer Information (Cerner Multum)
  • Sinequan Advanced Consumer (Micromedex) - Includes Dosage Information
  • Doxepin Prescribing Information (FDA)

See Also...

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