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Drugs reference index «Sodium Tetradecyl Sulfate»

Sodium Tetradecyl Sulfate

Sodium Tetradecyl Sulfate

Pronunciation: (SO-dee-uhm TEH-trah-dek-ill SULL-fate)Class: Sclerosing agent

Trade Names:Sotradecol- Injection 10 mg/mL- Injection 30 mg/mL


Causes venous intima inflammation and thrombus formation, which occludes the injected vein and subsequently forms fibrous tissue that results in partial or complete vein obliteration.

Indications and Usage

Treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.

Unlabeled Uses

Bleeding esophageal varices.


Acute superficial thrombophlebitis; valvular or deep vein incompetence; huge superficial veins with wide open communications to deeper veins; phlebitis migrans; acute cellulitis; allergic conditions; acute infections; varicosities caused by abdominal and pelvic tumors unless tumor has been removed; bedridden patients; uncontrolled systemic diseases such as diabetes, toxic hyperthyroidism, tuberculosis, asthma, neoplasm, sepsis, blood dyscrasias, acute respiratory or skin disease; hypersensitivity to any component of the product.

Dosage and Administration


IV Dose varies with size and degree of varicosity. In general, 1% solution is most useful, and the 3% solution is preferred for larger varicosities.


Store vials at controlled room temperature (68° to 77°F).

Drug Interactions

None well documented.


Heparin should not be included in the same syringe.

Laboratory Test Interactions

None well documented.

Adverse Reactions




Permanent discoloration along path of sclerosed vein.


Nausea; vomiting.


Pain; sloughing and necrosis of tissue following extravasation; ulceration at injection site; urticaria.


Allergic reactions including anaphylactic shock, asthma, hay fever, and hives.



Category C .




Safety and efficacy not established.

Special Risk Patients

Use with extreme caution in the presence of underlying arterial disease (eg, marked peripheral arteriosclerosis, thromboangiitis obliterans).

Deep vein thrombosis and pulmonary embolism

May occur.

Thrombosis extension

The risk of thrombosis extension into the deep venous system exists.

Patient Information

  • Advise patient or caregiver that medication will be prepared and administered by health care professionals in a medical setting.
  • Instruct patient to notify health care provider immediately if any of the following occur: hives, persistent pain, ulceration, or skin sloughing at injection site; pain, swelling, and/or redness of leg in which sodium tetradecyl was injected; sudden or unexplained shortness of breath and/or chest pain.
  • Advise patient that a permanent discoloring may develop along the path of the sclerosed vein segment.

Copyright © 2009 Wolters Kluwer Health.

  • Sodium Tetradecyl Sulfate MedFacts Consumer Leaflet (Wolters Kluwer)
  • sodium tetradecyl sulfate Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • Sotradecol Prescribing Information (FDA)

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