Drugs Information Online
Drugs and diseases reference index

Drugs and diseases reference index

Drugs reference index «Vfend I.V.»

Vfend I.V.
Vfend I.V.

Vfend I.V.

Generic Name: voriconazole (Oral route, Intravenous route)


Commonly used brand name(s):

In the U.S.

  • Vfend
  • Vfend I.V.

Available Dosage Forms:

  • Powder for Suspension
  • Tablet
  • Powder for Solution

Therapeutic Class: Antifungal

Chemical Class: Triazole

Uses For Vfend I.V.

Voriconazole is used to treat different kinds of serious fungal infections. It may also be used to treat patients with serious fungal infections who cannot tolerate other types of treatment or do not respond to other types of treatment.

This medicine is available only with your doctor's prescription.

Before Using Vfend I.V.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of voriconazole in children up to 12 years of age. Safety and efficacy have not been established .


Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of voriconazole in the elderly .


Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Astemizole
  • Carbamazepine
  • Cisapride
  • Dihydroergotamine
  • Dronedarone
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Mephobarbital
  • Methylergonovine
  • Methysergide
  • Phenobarbital
  • Pimozide
  • Quinidine
  • Rifabutin
  • Rifampin
  • Ritonavir
  • Sirolimus
  • St John's Wort
  • Terfenadine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Alprazolam
  • Amiodarone
  • Bretylium
  • Chloramphenicol
  • Clarithromycin
  • Clopidogrel
  • Cyclosporine
  • Darunavir
  • Dasatinib
  • Delavirdine
  • Dicumarol
  • Dofetilide
  • Efavirenz
  • Erythromycin
  • Etravirine
  • Everolimus
  • Fosphenytoin
  • Ibutilide
  • Ixabepilone
  • Lapatinib
  • Lopinavir
  • Nevirapine
  • Nilotinib
  • Pazopanib
  • Phenprocoumon
  • Phenytoin
  • Ranolazine
  • Romidepsin
  • Sotalol
  • Sunitinib
  • Tacrolimus
  • Telavancin
  • Temsirolimus
  • Triazolam
  • Vinblastine
  • Vincristine
  • Vincristine Liposome
  • Vinorelbine
  • Warfarin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Amprenavir
  • Atorvastatin
  • Cerivastatin
  • Ethinyl Estradiol
  • Fosamprenavir
  • Glipizide
  • Glyburide
  • Lovastatin
  • Meloxicam
  • Methadone
  • Midazolam
  • Nelfinavir
  • Norethindrone
  • Omeprazole
  • Oxycodone
  • Saquinavir
  • Simvastatin
  • Tolbutamide
  • Tretinoin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Cancer treatment (e.g., chemotherapy), history of or
  • Heart disease, history of or
  • Mineral imbalance (e.g., low potassium, magnesium, or calcium in the blood) or
  • Stem cell transplant—Use with caution. These conditions may increase your risk of having serious side effects
  • Galactose intolerance or
  • Glucose-galactose malabsorption or
  • Lapp lactase deficiency—Use with caution. The tablet form of this medicine contains lactose (milk sugar) and the oral liquid contains sucrose (table sugar) .
  • Heart rhythm problems (e.g., QT prolongation) or
  • Liver problems—May make these conditions worse .

Proper Use of voriconazole

This section provides information on the proper use of a number of products that contain voriconazole. It may not be specific to Vfend I.V.. Please read with care.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

A nurse or other trained health professional will give you the IV form of this medicine. This medicine is given through a needle placed in one of your veins. It will be given slowly, so the needle will remain in place for up to 2 hours .

For the oral suspension, shake well before measuring the dose. Use the oral dispenser supplied with your medicine to measure the dose.

  • For oral dosage forms (oral suspension or tablets):
    • For serious fungal infections:
      • Adults and children 12 years of age and above—Your dose will be determined based on your weight and other medicines you are taking. Check with your doctor for more dosage information. Oral suspension or tablets should be taken 1 hour before or after a meal.
      • Children below 12 years of age—Use and dose will be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused oral suspension after the date listed on the label.

Precautions While Using Vfend I.V.

It is very important that your doctor check you at regular visits to see if the medicine is working properly and decide if you should continue to take it.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Your doctor will discuss with you any changes in your medicine. Ask your doctor if you have any questions .

You should NOT use any of the following medicines while you are using voriconazole :

  • Astemizole (e.g., Hismanal®)
  • Carbamazepine (e.g., Tegretol®)
  • Cisapride (e.g., Propulsid®)
  • Ergot medicines (e.g., ergotamine, dihydroergotamine, methysergide, bromocriptine, Sansert®, or Parlodel®)
  • Phenobarbital (e.g., Luminal®)
  • Pimozide (e.g., Orap®)
  • Quinidine (e.g., Quinora®)
  • Rifabutin (e.g., Mycobutin®)
  • Rifampin (e.g., Rifadin®)
  • Sirolimus (e.g., Rapamune®)
  • St. John's wort
  • Terfenadine (e.g., Seldane®)

Check with your doctor first before using efavirenz (Sustiva®) or ritonavir (Norvir®) during voriconazole treatment. Your doses of these medicines will need to be adjusted .

This medicine may cause some people to have changes in vision, such as blurred vision and seeing bright spots or wavy lines. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you have vision changes.

Using this medicine while you are pregnant can harm your unborn baby. It is important that contraception (birth control) be used during treatment with this medicine. If you think you have become pregnant while using this medicine, tell your doctor right away .

The IV form of this medicine may cause a serious side effect called an infusion reaction. This can be life-threatening and require immediate medical attention. Tell your doctor or nurse right away if you have fever, chills, trouble with breathing, lightheadedness, fainting, or chest tightness within a few hours after you receive it .

This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds .

Vfend I.V. Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Rash
Less common
  • Abdominal or stomach pain
  • bloating or swelling of face, arms, hands, lower legs, or feet
  • blurred vision
  • chills
  • clay-colored stools
  • confusion
  • convulsions
  • dark urine
  • decreased urine
  • dizziness
  • dry mouth
  • faintness or light-headedness when getting up from a lying or sitting position
  • fever
  • headache
  • increased thirst
  • irregular or pounding heartbeat
  • itching
  • loss of appetite
  • mood or mental changes
  • muscle pain or cramps
  • muscle spasms or twitching
  • nausea
  • nervousness
  • numbness or tingling in hands, feet, or lips
  • pounding in the ears
  • rapid weight gain
  • rash with flat lesions or small raised lesions on the skin
  • shortness of breath
  • slow or fast heartbeat
  • suddenly sweating
  • trembling
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vasodilation (flushing)
  • vomiting of blood
  • yellow eyes or skin
  • Abnormal kidney function
  • black, bloody, or tarry stools
  • bleeding gums
  • blood in eye
  • blood in urine or stools
  • chest pain
  • eye pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on skin
  • redness in whites of eyes
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sudden kidney failure
  • swollen glands
  • trouble breathing with activity
  • unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

  • Change in color vision
  • difficulty seeing at night
  • increased sensitivity of eyes to sunlight

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common
  • Seeing things that are not there
Less common
  • Diarrhea
  • disturbance in vision
  • dry mouth
  • feeling unusually cold
  • shivering
  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Comment «Vfend I.V.»