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Drugs reference index «Abciximab»



Pronunciation: (ab-SIX-i-mab)Class: Glycoprotein IIb/IIIa inhibitor

Trade Names:ReoPro- Injection 2 mg/mL


Binds to glycoprotein IIb/IIIa receptors on surface of platelets, thereby preventing platelet aggregation.



Rapidly binds to glycoprotein IIb/IIIa receptors.


Initial t ½ is less than 10 min. Second phase t ½ is about 30 min.


Platelet function generally recovers over 48 h.

Indications and Usage

Adjunct to percutaneous coronary intervention (PCI) for the prevention of cardiac ischemic complications in patients undergoing PCI and in patients with unstable angina not responding to conventional medical therapy when PCI is planned within 24 h. Intended for use with aspirin and heparin.

Unlabeled Uses

Early treatment of MI; treatment of acute ischemic stroke.


Active internal bleeding; recent (6 wk) GI/GU bleeding, major surgery, or trauma; history of cerebrovascular accident (CVA) within the past 2 yr or CVA with significant residual neurological deficit; use of oral anticoagulants within 7 days unless PT is equal to or less than 1.2 times control; thrombocytopenia; severe uncontrolled hypertension; vasculitis; intracranial neoplasm, aneurysm, or arteriovenous malformation; the recent or current use of IV dextran; bleeding diathesis; or hypersensitivity to any component of the product or murine proteins.

Dosage and Administration


IV 0.25 mg/kg bolus 10 to 60 min before PCI followed by continuous infusion of 0.125 mcg/kg/min (to a max of 10 mcg/min) for 12 h.

Patients with unstable angina not responding to conventional medical treatment and who are planning to undergo PCI within 24 h may be treated with 0.25 mg/kg IV bolus followed by an 18- to 24-h IV infusion of 10 mcg/min, concluding 1 h after the PCI.

General Advice

  • Use only normal saline or D5W for IV infusion. Add no other medication for the infusion.
  • Do not use drug if vial contains visibly opaque particles.
  • Withdraw medication through a 0.2 or 5 micron filter.
  • Administer drug through a separate IV line with filter.
  • Avoid noncompressible sites when obtaining IV access.


Store vials at 2° to 8°C (36° to 46°F). Do not freeze. Do not shake. Discard any unused portion.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Hypotension (14%); bradycardia (5%); tachycardia (1%).


Headache (6%); dizziness (3%); anxiety (2%); abnormal thinking (1%).


Increased sweating (1%).


Nausea (14%); vomiting (7%); abdominal pain (3%); dyspepsia (2%); diarrhea (1%).


Anemia (1%); major bleeding (including intracranial hemorrhage), minor bleeding (including gross hematuria, spontaneous hematemesis), thrombocytopenia.


Back pain (18%).


Chest pain (11%); pain (5%); peripheral edema (2%); allergic reactions including anaphylaxis.




If serious bleeding occurs that is not controlled with pressure, stop infusion of abciximab and any concomitant heparin.

Platelet counts

Prior to administration, check platelet count, PTT, and APTT. Monitor during and after treatment.


Category C .




Safety and efficacy not established.


Abciximab may cause antibody development. Readministration may be associated with allergic reactions.


Because risk of bleeding is increased, use cautiously, if at all, with thrombolytics, oral anticoagulants, NSAIDs, dipyridamole, and ticlopidine. Institute bleeding precautions.


Monitor platelet counts.

Allergic reactions

Allergic reactions, including anaphylaxis (sometimes fatal), have been reported.

Femoral artery access

Care should be taken when attempting vascular access so that only the anterior wall of the femoral artery is punctured.

Restoration of platelet function

In the event of serious uncontrolled bleeding or the need for emergency surgery, if platelet function does not return to normal after discontinuing abciximab, it may be restored (at least in part) with platelet transfusions.

Vascular and other trauma

Minimize other arterial and venous punctures, epidural procedures, IM injections, and use of urinary catheters, nasotracheal intubation, and nasogastric tubes.



No experience of overdosage in clinical trials.

Patient Information

  • Advise patient to report any bleeding or bruising to health care provider immediately.

Copyright © 2009 Wolters Kluwer Health.

  • Abciximab MedFacts Consumer Leaflet (Wolters Kluwer)
  • abciximab Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • ReoPro Prescribing Information (FDA)
  • ReoPro Consumer Overview

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