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Definition of «Syndrome, Cushing»

Syndrome, CushingSyndrome, CushingSyndrome, CushingSyndrome, Cushing

Syndrome, Cushing: The constellation of symptoms and signs caused by an excess of cortisol hormone.

Cushing syndrome is an extremely complex hormonal condition that involves many areas of the body. Common symptoms are thinning of the skin, weakness, weight gain, bruising, hypertension, diabetes, thin weak bones (osteoporosis), facial puffiness and, in women, cessation of menstrual periods.

Ironically, one of the commonest causes of Cushing syndrome is the administration of "cortisol-like medications" for the treatment of diverse diseases. All other cases of Cushing syndrome are due to the excess production of cortisol by the adrenal gland as, for example, due to:

  1. An abnormal growth of the pituitary gland, which can stimulate the adrenal gland;
  2. A benign or malignant growth within the adrenal gland itself, which produces cortisol; or
  3. Production within another part of the body (ectopic production) of a hormone that directly or indirectly stimulates the adrenal gland to make cortisol.

The neurosurgeon Harvey Cushing (1869-1939) described excessive production of cortisol by the adrenal gland due specifically to an ACTH-secreting pituitary adenoma, a benign pituitary tumor that puts out ACTH (AdrenoCorticoTropic Hormone). This drives the adrenal gland to overproduce cortisol.

For More Information «Syndrome, Cushing»

  • Cushing's syndrome: Definition from Answers.com

    Library > Literature & Language > Dictionary n. A syndrome caused by an increased production of ACTH from a tumor of the adrenal cortex or of the anterior lobe of the ...

  • Cushing's syndrome

    Connect with others who've been there. Share stories. Learn. Join Mayo Clinic's Cushing's syndrome occurs when your body is exposed to high levels of the hormone ...

  • Cushing syndrome - PubMed Health - National Center for ...

    Cushing syndrome is a disorder that occurs when your body is exposed to high levels of the hormone cortisol. It may also occur if you take too much cortisol or ...

  • Cushing syndrome: MedlinePlus Medical Encyclopedia

    Cushing syndrome is a disorder that occurs when your body is exposed to high levels of the hormone cortisol. It may also occur if you take too much ...

  • Cushing Syndrome

    Cushing syndrome is caused by prolonged exposure to elevated levels of either endogenous glucocorticoids or exogenous glucocorticoids.

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