Van der Woude syndrome: A genetic disorder characterized by pits of the lower lip and by cleft lip and/or cleft palate. It is the most common known cleft syndrome.
The van der Woude syndrome is highly variable in its expression from person to person. There may be cleft lip, cleft palate, or both. The lip pits may be associated with accessory salivary glands that empty into the pits, leading to visible discharge.
The syndrome is inherited in an autosomal dominant manner. It is due to mutation of the IRF6 gene (interferon regulatory factor 6) on chromosome 1. The same gene is mutated in the popliteal pterygium syndrome, another disorder with cleft lip/palate and lip pits.
Van der Woude syndrome is a condition that affects the development of the face. Many people with this disorder are born with a cleft lip, a cleft palate (an ...
van der Woude syndrome is an autosomal dominant syndrome characterized by a , distinctive pits of the lower lips, or both.
The most commonly recognized syndrome associated with clefts of the lip and palate is Van der Woude syndrome. This syndrome is an autosomal dominant disorder ...
Van der Woude syndrome is an inherited form of cleft lip and palate. Children with van der Woude syndrome may have pits or mounds in the lower lip, too.
Article describes van der Woude syndrome, its symptoms, diagnosis, and treatment.