Pronunciation: (fen-AZZ-oh-PIH-rih-deen HIGH-droe-KLOR-ide)Class: Interstitial cystitis agent
Trade Names:Azo-Gesic- Tablets 95 mg
Trade Names:Azo-Septic- Tablets 95 mg
Trade Names:Azo-Standard- Tablets 95 mg
Trade Names:Baridium- Tablets 97 mg
Trade Names:Pyridium- Tablets 100 mg- Tablets 200 mgPhenazo
Exerts topical analgesic effect on urinary tract mucosa.
Phenazopyridine metabolism is probably hepatic; also in other body tissues. One active metabolite is acetaminophen.
Phenazopyridine is rapidly excreted by the kidneys, 65% as unchanged drug and metabolites.
Indications and Usage
Symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of lower urinary tract mucosa.
Dosage and AdministrationAdults
PO 200 mg 3 times daily.Children 6 to 12 yr of age
PO 12 mg/kg/24 h divided into 3 doses for 2 days.
- Administer after meals to avoid GI irritation.
- Do not crush tablets or make into a suspension.
Store at controlled room temperature (59° to 86°F).
None well documented.
Laboratory Test Interactions
Possible interference with colorimetric lab test procedures and urinalysis based on spectrometry or color reactions.
Occasional GI disturbances.
Methemoglobinemia; hemolytic anemia.
Category B .
May lead to accumulation, indicated by yellow tinge to skin and sclera.
Methemoglobinemia, hemolytic anemia, hemolysis, renal and hepatic function impairment and failure.
- Inform patient that this drug should not be taken long term for undiagnosed urinary tract pain.
- Advise patient to take drug after meals to avoid GI upset.
- Inform patient that urine may temporarily become reddish-orange in color and may stain fabric.
- Advise patient to wear glasses instead of contact lenses while taking this drug; contact lenses may become discolored.
- Inform patients with diabetes of possible interference with urine glucose test results.
- Instruct patient not to crush or chew tablets. Permanent teeth discoloration may occur.
- Instruct patient that if skin or sclera become yellowish in color, to discontinue drug and notify health care provider.
- Instruct patient to notify health care provider if headache, rash, pruritus, upset stomach, dizziness, or difficulty breathing occurs.
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