Generic Name: dalfopristin and quinupristin (dal FOE pris tin and kwi NYOO pris tin)Brand Names: Synercid
Dalfopristin and quinupristin is a combination antibiotic that fights severe or life-threatening infection caused by bacteria.
Dalfopristin and quinupristin is used to treat severe infections in the blood and other body systems.
Dalfopristin and quinupristin may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Synercid (dalfopristin and quinupristin)?You should not receive this medication if you are allergic to dalfopristin and quinupristin.
Before receiving dalfopristin and quinupristin, tell your doctor if you have liver or kidney disease, or a history of any type of allergy.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.What should I discuss with my health care provider before receiving Synercid (dalfopristin and quinupristin)?You should not receive this medication if you are allergic to dalfopristin and quinupristin.
If you have certain conditions, you may need a dose adjustment or special tests to safely receive this medication. Before you receive dalfopristin and quinupristin, tell your doctor if you are allergic to any drugs, or if you have:
kidney disease; or
a history of any type of allergy.
Dalfopristin and quinupristin is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection.
Dalfopristin and quinupristin is most often given in a hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 1 hour or longer to complete.
Dalfopristin and quinupristin is usually given for at least 7 days, or longer for more severe infections.
Since this medicine is usually given in a hospital, it is not likely that you will miss a dose.
Overdose can cause vomiting, trouble breathing, tremors, shaking, and loss of balance or coordination.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
diarrhea that is watery or bloody;
jaundice (yellowing of the skin or eyes);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
confusion, seizure (convulsions);
feeling light-headed, fainting;
pale skin, easy bruising or bleeding, unusual weakness; or
fever, chills, body aches, flu symptoms.
Less serious side effects may include:
joint or muscle pain;
mild skin rash or itching;
nausea, vomiting, constipation;
sleep problems (insomnia);
vaginal itching or discharge; or
pain, swelling, or irritation where the IV needle is placed.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before receiving dalfopristin and quinupristin, tell your doctor if you are using any of the following drugs:
digoxin (digitalis, Lanoxin);
diazepam (Valium) or midazolam (Versed);
methylprednisolone (Medrol, Duralone, Medipred, and others);
cyclosporine (Gengraf, Neoral, Sandimmune), tacrolimus (Prograf);
cancer medications such as vinblastine (Velban), vincristine (Oncovin), vinorelbine (Navelbine), docetaxel (Taxotere), paclitaxel (Taxol);
a calcium channel blocker such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV or AIDS medications such as delavirdine (Rescriptor), indinavir (Crixivan), nevirapine (Viramune), or ritonavir (Norvir); or
heart rhythm medications such as disopyramide (Norpace), lidocaine, or quinidine (Quinaglute, Quinidex).
This list is not complete and there may be other drugs that can interact with dalfopristin and quinupristin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.