Trade Names:Diethylpropion Hydrochloride- Tablets 25 mg- Tablets, sustained-release 75 mg
Stimulates satiety center in brain, causing appetite suppression.
Crosses the blood-brain barrier and the placenta.
Extensively metabolized, involving N-dealkylation and reduction, to many active metabolites.
75% to 100% excreted in the urine. Plasma t ½ of aminoketone metabolites is 4 to 6 h.
Short-term (few weeks) adjunct to diet plan to reduce weight.
Advanced arteriosclerosis; symptomatic cardiovascular disease; moderate to severe hypertension; hyperthyroidism; hypersensitivity to sympathomimetic amines; glaucoma; agitated states; history of drug abuse; concurrent use with or within 14 days of MAOI; coadministration with other CNS stimulants.
PO Immediate-release tablets 25 mg 3 times daily, 1 h before meals; Sustained-release tablets 75 mg once daily, in mid-morning. Do not crush or open sustained-release tablets.
May decrease hypotensive effect.MAOIs, furazolidone
Hypertensive crisis and intracranial hemorrhage may occur.SSRIs
Sympathomimetic effects of diethylpropion may be increased; increased risk of serotonin syndrome.Tricyclic antidepressants
May decrease anorexiant effect.
None well documented.
Palpitations; tachycardia; arrhythmias; hypertension; hypotension.
Overstimulation; dizziness; insomnia; euphoria; tremor; headache.
Excessive sweating; flushing.
Mydriasis; blurred vision.
Dry mouth; unpleasant taste; nausea; diarrhea; constipation; stomach pain.
Dysuria; urinary frequency; impotence; menstrual disturbances.
Bone marrow depression; agranulocytosis; leukopenia.
Hair loss; myalgia; gynecomastia; allergic reactions (eg, urticaria; rash; erythema).
Withhold medication if there is a BP increase of 20 mm Hg or if heart dysrhythmia or increase in heart rate develop.
Category B .
Excreted in breast milk.
Not recommended in children younger than 16 yr of age.
Diethylpropion may cause or aggravate hypertension or arrhythmias.
Diethylpropion may aggravate convulsions; dose titration or discontinuance may be necessary.
Related to amphetamine; has abuse potential.
Tolerance may occur.
Restlessness, tremor, hyperreflexia, fever, tachypnea, dizziness, panic, aggression, hallucinations, seizure, coma, arrhythmias, hypotension, hypertension, death.
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