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Drugs reference index «Diflorasone Diacetate»

Diflorasone Diacetate

Pronunciation: (die-FLORE-ah-sone die-ASS-eh-tate)Class: Topical corticosteroid

Trade Names:Psorcon E- Cream 0.05%- Ointment 0.05%


Therapeutic effects are caused by anti-inflammatory activity which are nonspecific (ie, they act against most causes of inflammation including mechanical, chemical, microbiological, and immunological).

Indications and Usage

Relief of the anti-inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.


Standard considerations.

Dosage and Administration

Occlusive dressings may be used for certain conditions.


Topical Apply sparingly to affected area 1 to 3 times/day.


Topical Apply sparingly to affected area 1 to 4 times/day.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

These may occur more frequently with occlusive dressings.


Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hypopigmentation; perioral dermatitis; allergic contact dermatitis; skin maceration; secondary infection; skin atrophy; striae; miliaria.


Systemic absorption may produce reversible hypothalamic pituitary adrenal (HPA) axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glycosuria.



Category C .


Use with caution. It is not known whether topical corticosteroids could result in sufficient systemic absorption to produce adverse reactions in infants.


Children may be more susceptible to topical corticosteroid-induced HPA axis suppression and Cushing syndrome than adults because of larger skin surface area to body weight ratio.

Systemic effects

Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, Cushing syndrome, hyperglycemia, and glycosuria. Conditions that may augment systemic absorption include use over large body surface areas, prolonged use, and occlusive dressings.

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