Brand names: Migranal
Migranal Nasal Spray is used for relief of migraine headache attacks, whether or not preceded by an aura (visual disturbances, usually including sensations of halos or flickering lights).
This nasally administered remedy contains the same active ingredient as D.H.E. 45, an injectable form of the drug. It constricts the blood vessels, and may defeat migraine through this action.
Migranal Nasal Spray is for use only during a genuine attack of classic migraine. Do not attempt to prevent migraines with Dihydroergotamine mesylate, and do not use it for tension headaches, cluster headaches, or unusual types of migraine such as hemiplegic or basilar migraine.
Migranal comes in single-dose ampuls, each with an accompanying nasal sprayer. Do not open an ampul until needed. Once opened, the drug must be used within 8 hours to be fully effective.
Take Dihydroergotamine mesylate at the first sign of a developing migraine. Assemble the ampul and sprayer according to package directions, pump the sprayer 4 times to prime it with medication, then spray once in each nostril. While spraying, do NOT tilt your head back or inhale through your nose. Wait 15 minutes, then spray once in each nostril again. After the second spray, discard the sprayer and the ampul's cap. To be prepared for the next attack, remember to load a new ampul and sprayer into the assembly case that comes with the medication.
Migranal will be effective even if you have a stuffy nose, a cold, or allergies.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Migranal Nasal Spray.
Do not take Migranal if you have ever had an allergic reaction to an ergotamine-based drug such as the migraine remedies ergotamine and dihydroergotamine or the senility drug ergoloid.
You should avoid Migranal if you have certain types of heart or blood vessel disease, including angina (crushing chest pain) or a history of heart attack, or if you suffer from uncontrolled high blood pressure, severe kidney or liver disease, or a severe blood infection. Avoid it, too, if you have recently had blood vessel surgery.
Do not use Migranal within 24 hours of taking another ergotamine-based drug, another migraine remedy such as naratriptan, rizatriptan, sumatriptan, or zolmitriptan, or the migraine-preventing drug methylsergide. Also avoid combining Migranal with other drugs that constrict the blood vessels, such as the decongestants pseudoephedrine and phenylpropanolamine found in many over-the-counter cold products.
Do not use Migranal Nasal Spray while pregnant or nursing.
If you have heart disease, Migranal could trigger a serious problem. Risk factors for this disorder include high blood pressure, high cholesterol, diabetes, a family history of heart disease, smoking, and passing menopause. Your doctor will probably want to observe your reaction to the first dose of Migranal if any of these factors apply.
Because Migranal constricts blood vessels, you should use it with caution if you have circulation problems in your arms, legs, fingers, or toes. Use it cautiously, too, if you are being treated for high blood pressure; it occasionally aggravates the problem.
Alert your doctor immediately if you have any of the following side effects: pain in the arms and legs, numbness or tingling in your fingers or toes, coldness, pallor, weakness in the legs, chest pain, temporary speeding or slowing of the heart rate, swelling, itching, or a bluish color in your fingers and toes.
If Migranal is taken with certain other drugs, the effects of either can be increased, decreased, or altered. Completely avoid other migraine remedies and ergotamine-based drugs, and check with your doctor before combining Migranal with the following:AzithromycinClarithromycinErythromycinNicotine (from any source, including cigarettes, patches, or inhalers)PhenylpropanolaminePropranololPseudoephedrineTroleandomycin
Migranal can harm a developing baby; do not use it during pregnancy. Also avoid while breastfeeding. It appears in breast milk and may cause diarrhea, vomiting, weak pulse, and unstable blood pressure in a nursing infant.
Use one spray (0.5 milligram) in each nostril followed by another spray in each nostril 15 minutes later for a total of 4 sprays (2 milligrams).
Do not use more than 3 milligrams (6 sprays) in 24 hours or 4 milligrams (8 sprays) in 7 days.
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.