VACTERL association: A nonrandom association of birth defects. VACTERL is an mnemonic in which the letters V, A, C, T, E, R, and L each stand for one or more type of malformation:
The VACTERL association has been recurrently observed in newborn babies. It is more common in the children of diabetic mothers than in the general population. For some years that was all that was known about the cause of the VACTERL association.
The VACTERL association was linked in 2001 to inhibition of cholesterol synthesis and down-regulation (the damping down) of what is called the cholesterol-dependent sonic hedgehog morphogenetic pathway. (This is a biochemical pathway in the shaping of the embryo that requires cholesterol.)
Case reports have suggested that the VACTERL association may possibly occur with increased frequency in children whose mothers have taken the cholesterol-lowering statin drugs in the first trimester of pregnancy. (These drugs are contraindicated in pregnancy.)
VACTERL: A nonrandom association was reported of vertebral defects, imperforate anus, and tracheoesophageal (TE) fistula was first reported in 1968. Over the years, the spectrum of malformations in the association was recognized to be broader. It became the VATER association (or VATERS association) and, now, has been extended as the VACTERL association.
Association: In dysmorphology (the study of birth defects), the term "association" refers to the nonrandom occurrence in two or more individuals of a pattern of multiple anomalies (birth defects) not known to be a malformation syndrome (such as Down syndrome), a malformation sequence (of events) or a polytopic field defect (in which all of the defects are concentrated in one particular area of the body).
VACTERL (VATER) Association causes defects, heart problems and prognosis from the Heart Encyclopedia by Cincinnati Children's Hospital Medical Center staff.
VACTERL association: A nonrandom association of birth defects. VACTERL is an mnemonic in which the letters V, A, C, T, E, R, and L each stand for one or more type of ...
VACTERL Association Support Group giving help and support to families affected by VACTERL Association or VATER Syndrome.
Important It is possible that the main title of the report VACTERL Association is not the name you expected. Please check the synonyms listing to find the ...
VACTERL Association Abstract. You are reading a NORD Rare Disease Report Abstract. NORDâ€™s full collection of reports on over 1200 rare diseases is available to subscribers ...